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MCI Research Opportunities

 

The Shiley-Marcos Alzheimer’s Disease Research Center has a wide variety of opportunities for volunteers to participate in important research studies designed to discover ways to prevent, treat, and ultimately eradicate Alzheimer’s disease. We are recruiting diverse volunteers on an ongoing basis to learn more about memory and aging.

Research Registry

Are you interested in participating in a research study but don't currently see one that suits you? You can now join our Research Registry to be placed on a list for future studies. 

*Call the ADRC 858-822-4800 and ask for Christina Gigliotti, Ph.D. for more information on being added to the registry or to determine your eligibilty for any of our enrolling studies.

 

Currently Enrolling New Participants

 

Observational Studies

Memory Impaired Longitudinal Study

Clinical Trials

Merck 19:  EPOCH

PI:  Shauna Yuan, MD     Contact:  Christina Gigliotti, PhD  858-822-4800 (cgigliotti@ucsd.edu)

Time involved: 104 weeks of treatment; 12 visits over 24 months

Description:  BACE inhibitor designed to stop the action of an enzyme required to make beta amyloid. 2/3 get study drug; 1/3 at low dose; 1/3 at high dose.  Drug administered as one tablet once a day.

Requirements: Age 50-85; stable on memory medication for 3 months or no memory medications, 5 MRIs, 6 ocular exams, 1 PET scan, study partner

 

Other Research

Amy Jak, PhD is conducting a study with persons who have a diagnosis of MCI called: "Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI." Click here to read the study brochure. For more information or to participate contact sjurick@ucsd.edu or 858-552-8585 x 2670.

Research Registry

Are you interested in participating in a research study but don't currently see one that suits you? You can now join our Research Registry to be placed on a list for future studies. 

*Call the ADRC 858-822-4800 and ask for Christina Gigliotti for more information.

 

Memory Impaired Longitudinal Study

Description

This is the primary research study at the ADRC. Data gathered from this longitudinal study has helped us learn about the clinical development and pathology of the disease. It has also helped us learn to discriminate among the various kinds of dementia, such as Parkinson’s disease, Lewy Body disease, and Pick’s disease (Frontotemporal dementia). We are currently studying pre-clinical and the very earliest stages of the disease. We are able to provide testing to Hispanic, spanish speaking individuals in English and/or Spanish.

Candidate Criteria

Must have a diagnosis of MCI or mild to moderate dementia, a reliable study partner, stable health status, and must not have any history of major strokes.

 

Benefit

Two major benefits are having access to a staff member who evaluate your condition and who will...

(1) inform you of the results of the evaluations and

(2) make suggestions and referrals for coping with problems that you may have

Consultation with our social workers is also available as needed

Cost

There is no financial cost to participate in our longitudinal research study. The only cost to you is in travel, time, and effort involved in an annual evaluation.

You may withdraw at any time. We would, however like a commitment of a minimum of five years in order to gather the optimal longitudinal data.

Time/Procedures

Annual visits that last one and a half days. The annual exam consists of three parts: a nursing exam, a neuropsychological assessment, and a neurology exam. In addition, participants will be asked to undergo a volumetric brain MRI scan and a spinal fluid draw (lumbar punture procedure).

We also request that you agree to a brain autopsy. This is critical to our research, since the pathological confirmation is the only definitive diagnosis for the disease. It also provides tissue for critical studies in the pathophysiology of the disease.

 

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